• Thank you for visiting the Cafe Rad Lab Forum
  • We present & discuss radiation health, science & news
  • To keep you informed about vital nuke information.
Hello There, Guest! Login Register


Thread Rating:
  • 0 Vote(s) - 0 Average
  • 1
  • 2
  • 3
  • 4
  • 5
bystander effect
#1
Radiation health science and radio-ecobiology has seen paradigm shifts.   

This is a great video explaining some of the new insights.   Im quite interested to see discussion of biophotons in mainstream science.   

 Low Level Radiation and Health Conference 2018 Prof Carmel Mothersill 'Biophotons'

https://www.youtube.com/watch?v=K2mmfiXpM6s


and some other quotes to illustrate the paradigm shift;

 "The key findings which have led to the NTE paradigm shift were that de novo effects can
be detected in both the surviving progeny and the neighbors of irradiated cells which were not induced by the direct action of radiation energy deposition in the cells showing the effects. While this seems quite expected today,
at the time it was considered as a heretical challenge to the dogma of target theory which stated that the effects of
radiation occurred in the DNA of the targeted cell"

"Non-DNA targeted effects of ionizing radiation, which include genomic instability, and a variety of bystander effects including abscopal effects and bystander mediated adaptive response, have raised concerns about the magnitude of low-dose radiation risk. Genomic instability, bystander effects and adaptive responses are powered by fundamental, but not clearly understood systems that maintain tissue homeostasis. Despite excellent research in this field by various groups, there are still gaps in our understanding of the likely mechanisms associated with non-DNA targeted effects, particularly with respect to systemic (human health) consequences at low and intermediate doses of ionizing radiation. "

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091999/


"Ionizing radiation was traditionally thought to exert its detrimental effects through interaction with sensitive cellular targets, nuclear DNA being of most importance. This theory has since merged with a more recently described radiation response called non-targeted effects (NTE). This review will briefly look at the various types of NTE and the potential implications they may have for radiobiology research and its applications. The most well-known NTE are genomic instability (GI) and bystander effects (BE). Other NTE include abscopal effects, which are similar to bystander effects but are generally based in a clinical environment with immune involvement as the defining feature. Currently, our understanding of NTE is limited to certain signaling pathways/molecules, and as yet there is no theory that describes or can accurately predict the occurrence or outcome of these NTE. There are numerous groups investigating these processes in vitro and in vivo, and thus steady progress is being made. Developing a deeper understanding of NTE has potential impacts for therapy and diagnosis, safer occupational exposures, space flight and our general understanding of radiation biology."

https://www.tandfonline.com/doi/full/10....src=recsys

"The risks of exposure to low dose ionizing radiation (below 100 mSv) are estimated by extrapolating from data obtained after exposure to high dose radiation, using a linear no-threshold model (LNT model). However, the validity of using this dose-response model is controversial because evidence accumulated over the past decade has indicated that living organisms, including humans, respond differently to low dose/low dose-rate radiation than they do to high dose/high dose-rate radiation. In other words, there are accumulated findings which cannot be explained by the classical "target theory" of radiation biology."
https://www.researchgate.net/publication..._Responses
we are healthy with background radiation but unhealthy with the same dose from fallout
 
Reply
  


Forum Jump:


Browsing: 1 Guest(s)